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Pyridine → 1-benzyl-N-[(3,4-difluorophenyl)methyl]-6-[(E)-hydroxyiminomethyl]-2-propan-2-ylindole-3-carboxamide

HRID 40079
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HRID 40079 반응식
[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([CH:17]=O)[CH:15]=2)[C:10]([C:19]([NH:21][CH2:22][C:23]2[CH:28]=[CH:27][C:26]([F:29])=[C:25]([F:30])[CH:24]=2)=[O:20])=[C:9]1[CH:31]([CH3:33])[CH3:32])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[NH2:35][OH:36].N1C=CC=CC=1>CO>[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14](/[CH:17]=[N:35]/[OH:36])[CH:15]=2)[C:10]([C:19]([NH:21][CH2:22][C:23]2[CH:28]=[CH:27][C:26]([F:29])=[C:25]([F:30])[CH:24]=2)=[O:20])=[C:9]1[CH:31]([CH3:33])[CH3:32])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1
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참가 물질

5

반응물 3

HCID 1049PyridineHCID 443297Hydroxyamine hydrochlorideHCID 597623731-Benzyl-N-(3,4-difluorobenzyl)-6-formyl-2-isopropyl-1H-indole-3-carboxamide2회

생성물 1

HCID 597623301-benzyl-N-[(3,4-difluorophenyl)methyl]-6-[(E)-hydroxyiminomethyl]-2-propan-2-ylindole-3-carboxamide

시약·촉매·용매 1

HCID 887Methanol용매

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온도
65 °C

실험 절차

To a solution of 1-benzyl-N-(3,4-difluorobenzyl)-6-formyl-2-isopropyl-1H-indole-3-carboxamide (Compound 53, 12 mg, 0.027 mmol) in MeOH (6 ml) was hydroxylamine hydrochloride (6.0 mg, 0.081 mmol) and pyridine (3 mg, 0.16 mmol). The mixture was stirred at 65° C. for 12 h, and then added concentrated in vacuo. The residue was purified by chromatography on silica gel (0→40% EtOAc-hexanes) to yield the title compound as a white solid.

후처리

  1. additionadded
  2. concentrationconcentrated in vacuo
  3. customThe residue was purified by chromatography on silica gel (0→40% EtOAc-hexanes)

출처 및 근거

ORD 기록
ord-0f3cc018b2cf48b5b14e8d6dd44d410e
출처 데이터셋
uspto-grants-2013_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08524917B2

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