Dimethylformamide → [2-(5-Fluoro-2,4-dinitro-phenyl)-vinyl]-dimethyl-amine

HRID 401275

반응식

HRID 401275 반응식
[F:1][C:2]1[CH:7]=[C:6]([CH3:8])[C:5]([N+:9]([O-:11])=[O:10])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13].CO[CH:17]([N:20]([CH3:22])[CH3:21])OC.CN(C=O)C>O>[F:1][C:2]1[C:3]([N+:12]([O-:14])=[O:13])=[CH:4][C:5]([N+:9]([O-:11])=[O:10])=[C:6]([CH:8]=[CH:17][N:20]([CH3:22])[CH3:21])[CH:7]=1

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 78373Dimethylformamide dimethyl acetalHCID 5207051-Fluoro-5-methyl-2,4-dinitrobenzene

생성물 1

HCID 57060726[2-(5-Fluoro-2,4-dinitro-phenyl)-vinyl]-dimethyl-amine수율 63%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
100 °C

실험 절차

A mixture of 1-fluoro-5-methyl-2,4-dinitro-benzene (10 g, 50 mmol), dimethoxymethyl-dimethylamine (11.9 g, 100 mmol) and DMF (50 mL) was heated at 100° C. for 4 h. The solution was cooled and poured into water. The red precipitate was collected via filtration, washed with water adequately and dried to give [2-(5-fluoro-2,4-dinitro-phenyl)-vinyl]-dimethyl-amine (8 g, 63%).

후처리

  1. temperatureThe solution was cooled
  2. filtrationThe red precipitate was collected via filtration
  3. washwashed with water adequately
  4. customdried

출처 및 근거

ORD 기록
ord-6f6e3b0b9c264bdc91c22d4cc7f9a5cb
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08741925B2

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