Ethylene Glycol → 3-(2-Hydroxyethyl)indolin-2-one

HRID 401371노트

반응식

HRID 401371 반응식
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C:2]1=[O:10].[CH2:11](O)[CH2:12][OH:13]>[Ni]>[OH:13][CH2:12][CH2:11][CH:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[NH:1][C:2]1=[O:10]

참가 물질

4

반응물 2

HCID 174Ethylene GlycolHCID 321710Oxindole

생성물 1

HCID 108992203-(2-Hydroxyethyl)indolin-2-one수율 70%

시약·촉매·용매 1

HCID 935Nickel촉매

실험 절차

A stifling mixture of oxindole (5.7 g, 43 mmol) and Raney nickel (10 g) in ethane-1,2-diol (100 mL) was heated in an autoclave. After the reaction was complete, the mixture was filtered and the excess of diol was removed under vacuum. The residual oil was triturated with hexane to give 3-(2-hydroxy-ethyl)-1,3-dihydro-indol-2-one as a colorless crystalline solid (4.6 g, 70%).

후처리

  1. temperaturewas heated in an autoclave
  2. filtrationthe mixture was filtered
  3. customthe excess of diol was removed under vacuum
  4. customThe residual oil was triturated with hexane

출처 및 근거

ORD 기록
ord-923023eac3304e00814ee021f7b24ab6
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08741925B2

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