2-Isopropyl-5-nitropyridine → 6-(Propan-2-yl)pyridin-3-amine

HRID 401412

반응식

HRID 401412 반응식
[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([N+:10]([O-])=O)=[CH:6][N:5]=1)([CH3:3])[CH3:2]>CO.[Ni]>[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([NH2:10])=[CH:6][N:5]=1)([CH3:3])[CH3:2]

참가 물질

4

반응물 1

HCID 450963212-Isopropyl-5-nitropyridine

생성물 1

HCID 178542886-(Propan-2-yl)pyridin-3-amine수율 52%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

2-Isopropyl-5-nitro-pyridine (1.30 g, 7.82 mmol) was dissolved in methyl alcohol (20 mL), and Raney Ni (0.25 g) was added. The mixture was stirred under H2 (1 atm) at room temperature for 2 h. The catalyst was filtered off, and the filtrate was concentrated under vacuum to give 2-isopropyl-5-amino-pyridine (E-9) (0.55 g, 52%). 1H NMR (CDCl3) δ 8.05 (s, 1H), 6.93-6.99 (m, 2H), 3.47 (br s, 2H), 2.92-3.02 (m, 1H), 1.24-1.26 (m, 6H). ESI-MS 137.2 m/z (MH+).

후처리

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated under vacuum

출처 및 근거

ORD 기록
ord-4d442da4c0be4e738d46ab1cfdb9deb3
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08741925B2

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