2-Methoxy-3-nitropyridine → 3-Amino-2-methoxypyridine

HRID 401585

반응식

HRID 401585 반응식
[CH3:1][O:2][C:3]1[C:8]([N+:9]([O-])=O)=[CH:7][CH:6]=[CH:5][N:4]=1>CO.[Pd]>[CH3:1][O:2][C:3]1[C:8]([NH2:9])=[CH:7][CH:6]=[CH:5][N:4]=1

참가 물질

4

반응물 1

HCID 2532192-Methoxy-3-nitropyridine

생성물 1

HCID 27374883-Amino-2-methoxypyridine수율 87%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A solution of 2-methoxy-3-nitro-pyridine (70. g, 0.45 mol) in methanol (700 mL) containing palladium on carbon (7 g, 10%) was stirred under an atmosphere of hydrogen for 15 hours. The catalyst was filtered and washed with methanol. The filtrate was evaporated to dryness to give crude 2-methoxy-pyridin-3-ylamine (48 g, 0.39 mol, 87%), which was used directly in the next step.

후처리

  1. filtrationThe catalyst was filtered
  2. washwashed with methanol
  3. customThe filtrate was evaporated to dryness

출처 및 근거

ORD 기록
ord-a4a258994c364f5d8376e8f8bf129688
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08741939B2

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