Lithium Hydroxide → 2-Cyclohexyl-1,3-thiazole-4-carboxylic acid

HRID 402182노트

반응식

HRID 402182 반응식
C([O:3][C:4]([C:6]1[N:7]=[C:8]([CH:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)[S:9][CH:10]=1)=[O:5])C.[Li+].[OH-]>O>[CH:11]1([C:8]2[S:9][CH:10]=[C:6]([C:4]([OH:5])=[O:3])[N:7]=2)[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]1

참가 물질

4

반응물 2

HCID 3939Lithium HydroxideHCID 57956421Ethyl 2-cyclohexylthiazole-4-carboxylate

생성물 1

HCID 234049342-Cyclohexyl-1,3-thiazole-4-carboxylic acid수율 83%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a solution of 2-cyclohexylthiazole-4-carboxylic acid ethyl ester (116, 6.8 g, 28.5 mmol) in water was added 1M LiOH (50 mL). The solution was kept at room temperature and monitored by LC-MS. When the hydrolysis was completed the reaction mixture was neutralized with myriatic acid and extracted with ethyl acetate and diethyl ether. The organic phase was dried (Na2SO4), filtered and concentrated under reduced pressure to give 5.0 g (83%) of the title compound 117: m/z=212 (M+H)+.

후처리

  1. customwas kept at room temperature
  2. extractionextracted with ethyl acetate and diethyl ether
  3. dry with materialThe organic phase was dried (Na2SO4)
  4. filtrationfiltered
  5. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-98ffb5f3389e43e1bc4eec0dab76d9f5
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08741926B2

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