Benzyl Chloride → Methyl 2,3-bis(benzyloxy)benzoate

HRID 402742노트

반응식

HRID 402742 반응식
[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([OH:10])[C:5]=1[OH:11].[CH2:13](Cl)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([O:10][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:5]=1[O:11][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

참가 물질

3

반응물 2

HCID 7503Benzyl ChlorideHCID 75484Methyl 2,3-Dihydroxybenzoate

생성물 1

HCID 10665397Methyl 2,3-bis(benzyloxy)benzoate

실험 절차

In one embodiment, the compounds can be prepared as shown in Scheme II. A dihydroxy benzoic acid methyl ester is reacted with benzyl chloride, to produce a Bis-benzyloxy benzoic acid methyl ester (1). The Bis-benzyloxy benzoic acid methyl ester can then be heated with LiOH to give a Bis-benzyloxy benzoic acid (2). The Bis-benzyloxy benzoic acid (2) is then reacted with an aminophenyl to produce a phenyl-benzamide (3). The phenyl-benzamide (3) is then reacted with hydrazine to give a triazol (4). The hydroxy groups can then be unprotected in the presence of palladium on charcoal to give the final product.

후처리

  1. customIn one embodiment, the compounds can be prepared

출처 및 근거

ORD 기록
ord-db7e5c64885149b6b3e793f919bfc830
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08742133B2

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