Potassium Carbonate → HCID 66765091, 화합물

HRID 402756

반응식

HRID 402756 반응식
C(=O)([O-])[O-].[K+].[K+].Cl.[C:8]1([NH:14][NH2:15])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.O=[C:17]([C:24]1[CH:29]=[C:28]([F:30])[C:27]([F:31])=[CH:26][C:25]=1[F:32])[CH2:18][C:19](OCC)=[O:20]>CCO>[C:8]1([N:14]2[C:19](=[O:20])[CH2:18][C:17]([C:24]3[CH:29]=[C:28]([F:30])[C:27]([F:31])=[CH:26][C:25]=3[F:32])=[N:15]2)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 60962Phenylhydrazine hydrochlorideHCID 2758933Ethyl 2,4,5-trifluorobenzoylacetate

생성물 1

HCID 66765091HCID 66765091, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
70 °C

실험 절차

Potassium carbonate (153 mg, 1.10 mmol) was added to a stirred mixture of phenyl hydrazine HCl salt (160 mg, 1.10 mmol) and ethyl 3-oxo-3-(2,4,5-trifluorophenyl)propanoate (272 mg, 1.10 mmol) in EtOH (6 mL) and the mixture was heated at 70° C. for 1 hour. The solution was cooled to room temperature and was concentrated to give the title compound, which was taken on to the next step.

후처리

  1. temperatureThe solution was cooled to room temperature
  2. concentrationwas concentrated

출처 및 근거

ORD 기록
ord-3b8aeac09dcf44bfbc8b68645c6200f3
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08742110B2

연결된 노트

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