Hydrochloric Acid → 4-Chloro-2-aminobutanoic acid hydrochloride

HRID 402968

반응식

HRID 402968 반응식
[NH2:1][C@H:2]([C:6]([OH:8])=[O:7])[CH2:3][CH2:4]O.S(=O)(=O)(O)O.[ClH:14].CO>O>[ClH:14].[Cl:14][CH2:4][CH2:3][CH:2]([NH2:1])[C:6]([OH:8])=[O:7]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 1118Sulfuric AcidHCID 12647L-Homoserine

생성물 1

HCID 566498294-Chloro-2-aminobutanoic acid hydrochloride

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
70 °C

실험 절차

Approximately 1 equivalent of homoserine, 0.01 equivalent of sulfuric acid may be combined with water in a reactor. The reactor may be sealed and 1.1 equivalent of anhydrous HCl (gas) may be may be added to the reactor. The reaction mixture may be heated to about 70° C. and maintained at about 80 psi for about 24 hours. The reaction mixture may be cooled and about 10 equivalents of methanol may be added, such that the product precipitates. The product (i.e., 4-chloro-2-aminobutanoic acid hydrochloride) may be isolated by filtration.

후처리

  1. customThe reactor may be sealed
  2. temperaturemaintained at about 80 psi for about 24 hours
  3. temperatureThe reaction mixture may be cooled
  4. customprecipitates

출처 및 근거

ORD 기록
ord-98ed8ec94aad4762a44ba907f07b4eb4
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08742170B2

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