Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 1-Bromo-4-(4-n-propylphenylethynyl)naphthalene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Heptane | HCID 8900 | — |
| 반응물 | 1-Ethynyl-4-propylbenzene | HCID 2775133 | — |
| 반응물 | 1-Bromo-4-iodonaphthalene | HCID 5073667 | — |
| 촉매 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 촉매 | HCID 178418476 | HCID 178418476 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | 1-Bromo-4-(4-n-propylphenylethynyl)naphthalene | HCID 67117851 | — |
반응 단계
15.3 g (43.6 mmol) of 1-iodo-4-bromonaphthalene and 7.25 g (5.3 mmol) of 4-n-propylphenylacetylene are initially introduced in 200 ml of NEt3, 170 mg (0.9 mmol) of copper(I) iodide and 600 mg (0.9 mmol) of bis-(triphenylphosphine)palladium(II) chloride are added, and the mixture is refluxed for 30 minutes. The batch is cooled, water and heptane are added, and the phases are separated. The organic phase is washed with saturated sodium chloride solution, dried over sodium sulfate, filtered and evaporated in a rotary evaporator. The residue is purified by column chromatography (SiO2, heptane), and the further purification is carried out by recrystallisation from isopropanol.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08747695B2 |
| 출처 데이터셋 | uspto-grants-2014_06 |
| ORD ID | ord-4ceefc20bc9a4030bd16717248086541 |
| 출처 메모 | uspto-grants-2014_06 |