反应详情

15.3 g (43.6 mmol) of 1-iodo-4-bromonaphthalene and 7.25 g (5.3 mmol) of 4-n-propylphenylacetylene are initially introduced in 200 ml of NEt3, 170 mg (0.9 mmol) of copper(I) iodide and 600 mg (0.9 mmol) of bis-(triphenylphosphine)palladium(II) chloride are added, and the mixture is refluxed for 30 minutes. The batch is cooled, water and heptane are added, and the phases are separated. The organic phase is washed with saturated sodium chloride solution, dried over sodium sulfate, filtered and evaporated in a rotary evaporator. The residue is purified by column chromatography (SiO2, heptane), and the further purification is carried out by recrystallisation from isopropanol.

1. temperaturethe mixture is refluxed for 30 minutes
2. temperatureThe batch is cooled
3. customthe phases are separated
4. washThe organic phase is washed with saturated sodium chloride solution
5. dry with materialdried over sodium sulfate
6. filtrationfiltered
7. customevaporated in a rotary evaporator
8. customThe residue is purified by column chromatography (SiO2, heptane)
9. customthe further purification
10. customis carried out by recrystallisation from isopropanol