Hydrochloric Acid → (S)-(3-(Azetidin-3-ylamino)pyrrolidin-1-yl)(phenyl)methanone

HRID 403287노트

반응식

HRID 403287 반응식
C(OC([N:8]1[CH2:11][CH:10]([NH:12][C@H:13]2[CH2:17][CH2:16][N:15]([C:18](=[O:25])[C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH2:14]2)[CH2:9]1)=O)(C)(C)C.Cl>CO.O1CCOCC1>[NH:8]1[CH2:9][CH:10]([NH:12][C@H:13]2[CH2:17][CH2:16][N:15]([C:18]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)=[O:25])[CH2:14]2)[CH2:11]1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 67288181(S)-tert-Butyl-3-((1-benzoylpyrrolidin-3-yl)amino)azetidine-1-carboxylate

생성물 1

HCID 67288563(S)-(3-(Azetidin-3-ylamino)pyrrolidin-1-yl)(phenyl)methanone

시약·촉매·용매 2

HCID 887Methanol용매HCID 312751,4-Dioxane용매

실험 절차

To a solution of compound 5d (0.96 g, 2.78 mmol) in MeOH (5 mL) was added HCl solution in dioxane (4M, 10 mL) at room temperature. The mixture was stirred at room temperature for 4 h. The solvent was removed by evaporation. Ether (50 mL) was added to the residue. The off-white solid was collected by filtration, washed with hexanes, and dried under vacuum. The crude compound 5e was used in the next reaction without further purification. MS m/z (M+H+) 246.0.

후처리

  1. customThe solvent was removed by evaporation
  2. additionEther (50 mL) was added to the residue
  3. filtrationThe off-white solid was collected by filtration
  4. washwashed with hexanes
  5. customdried under vacuum
  6. customThe crude compound 5e was used in the next reaction without further purification

출처 및 근거

ORD 기록
ord-60b883c7bd42414d99cde428f4ad3807
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08748417B2

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