Ethylacetate heptane → 6-chloro-N-methyl-4-phenylpyridazin-3-amine

HRID 403379

반응식

[Cl:1][C:2]1[N:7]=[N:6][C:5]([NH2:8])=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:3]=1.[CH3:15]CCCCCC.C(OCC)(=O)C>>[Cl:1][C:2]1[N:7]=[N:6][C:5]([NH:8][CH3:15])=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:3]=1

참가 물질

반응물 2

HCID 21899848Ethylacetate heptane

HCID 768487136-Chloro-4-phenylpyridazin-3-amine

생성물 1

HCID 866984786-chloro-N-methyl-4-phenylpyridazin-3-amine

실험 절차

The title compound was prepared in analogy to example 1, intermediate a, from 6-chloro-4-phenyl-pyridazin-3-ylamine and using a gradient of n-heptane:ethyl acetate (100:0 to 40:60) for the chromatographic purification. Light yellow solid (52%). MS (ESI+): m/z=220.064 ([M+H]+).

후처리

customfor the chromatographic purification

출처 및 근거

ORD 기록: ord-7e66c99393e84a34bdda062980d3e56e
출처 데이터셋: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08748434B2

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