Dimethylamine → 5-bromo-N,N-dimethyl-1,3-thiazol-2-amine

HRID 40343

반응식

HRID 40343 반응식
[CH2:1]([N:3]([CH:7](C)C)[CH:4](C)C)C.BrC1[S:12][C:13]([Br:16])=[CH:14][N:15]=1.CNC>C(O)C>[Br:16][C:13]1[S:12][C:7]([N:3]([CH3:1])[CH3:4])=[N:15][CH:14]=1

참가 물질

5

반응물 3

HCID 674DimethylamineHCID 81531DiisopropylethylamineHCID 3123942,5-Dibromothiazole

생성물 1

HCID 124485555-bromo-N,N-dimethyl-1,3-thiazol-2-amine수율 29.4%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
140 °C

실험 절차

To a microwave vial was added N-ethyl-N-isopropylpropan-2-amine (0.72 mL, 4.1 mmol), 2,5-dibromothiazole (1.00 g, 4.1 mmol) and dimethylamine (40% in water, 0.52 mL, 4.1 mmol) in ethanol (10 mL). The vial was sealed and stirred at 140° C. under microwave irradiation for one hour, then was concentrated and purified by MPLC (eluted with a gradient of 0-50% ethyl acetate in hexanes) to yield the product as a white, crystalline solid (0.25 g, 29%).

후처리

  1. customThe vial was sealed
  2. concentrationwas concentrated
  3. custompurified by MPLC (
  4. washeluted with a gradient of 0-50% ethyl acetate in hexanes)

출처 및 근거

ORD 기록
ord-b201cdf1bcef499aa1e592a42cc69f9d
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524900B2

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