Acetic Acid → 6-Bromo-1,2,3,4-tetrahydrocarbazole

HRID 403646노트

반응식

HRID 403646 반응식
Cl.[Br:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9]N)=[CH:5][CH:4]=1.[C:11](O)(=O)[CH3:12].C(=O)(O)[O-].[Na+]>C1(=O)CCCCC1>[Br:2][C:3]1[CH:8]=[C:7]2[C:6](=[CH:5][CH:4]=1)[NH:9][C:12]1[CH2:11][CH2:5][CH2:4][CH2:3][C:8]2=1

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 121574-Bromophenylhydrazine hydrochlorideHCID 516892Sodium Bicarbonate

생성물 1

HCID 2688776-Bromo-1,2,3,4-tetrahydrocarbazole

시약·촉매·용매 1

HCID 7967Cyclohexanone용매2회

실험 절차

Cyclohexanone (1.16 mL, 11.2 mmol) and 4-bromo-phenylhydrazine hydrochloride (2.50 g, 11.2 mmol) were refluxed in cyclohexanone (18 mL) and acetic acid (AcOH) (12 L) for 24 h. The reaction mixture was treated with saturated sodium bicarbonate (Na2CO3) and extracted with ethyl acetate, dried (Na2CO3) and concentrated. The product was purified by column chromatography, giving 479 mg of compound 30 as a solid.

후처리

  1. extractionextracted with ethyl acetate
  2. dry with materialdried (Na2CO3)
  3. concentrationconcentrated
  4. customThe product was purified by column chromatography

출처 및 근거

ORD 기록
ord-cc728d06680b4570a0af222d9319c9df
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08748451B2

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