Benzenamine, 3-ethynyl- → 4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yl acetate Hydrochloride

HRID 403663노트

반응식

HRID 403663 반응식
[C:1]([O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][C:14]=1[O:15][CH3:16])[N:11]=[CH:10][N:9]=[C:8]2[Cl:17])(=[O:3])[CH3:2].[C:18]([C:20]1[CH:21]=[C:22]([CH:24]=[CH:25][CH:26]=1)[NH2:23])#[CH:19]>C(Cl)(Cl)Cl>[ClH:17].[C:1]([O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][C:14]=1[O:15][CH3:16])[N:11]=[CH:10][N:9]=[C:8]2[NH:23][C:22]1[CH:24]=[CH:25][CH:26]=[C:20]([C:18]#[CH:19])[CH:21]=1)(=[O:3])[CH3:2]

참가 물질

4

반응물 2

HCID 104682Benzenamine, 3-ethynyl-HCID 220221604-Chloro-7-methoxyquinazolin-6-yl acetate

생성물 1

HCID 866599184-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yl acetate Hydrochloride수율 89.8%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

A mixture of 4-chloro-7-methoxyquinazolin-6-yl acetate (7.75 g, 0.0307 mol), 3-ethynyl aniline (4 g, 0.0342 mol, 1.11 equiv) and chloroform (120 ml) was refluxed overnight. The reaction mixture was cooled to room temperature and the solution was filtered to give 10.2 g product. MS (ESI) m/z: 334 (M+1).

후처리

  1. temperaturewas refluxed overnight
  2. filtrationthe solution was filtered

출처 및 근거

ORD 기록
ord-8f3681ffb6ad484ea8cae4a59c2ee67d
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08748453B2

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