1,3-Difluoro-5-isocyanatobenzene → HCID 67305419, 화합물

HRID 403714

반응식

HRID 403714 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:16]=[C:15]3[C:11]([CH2:12][N:13]([C@@H:18]([CH:23]([CH3:25])[CH3:24])[C:19]([O:21][CH3:22])=[O:20])[C:14]3=[O:17])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[F:26][C:27]1[CH:28]=[C:29]([N:34]=[C:35]=[O:36])[CH:30]=[C:31]([F:33])[CH:32]=1>>[CH3:22][O:21][C:19](=[O:20])[C@@H:18]([N:13]1[CH2:12][C:11]2[C:15](=[CH:16][C:8]([C:5]3[CH:4]=[CH:3][C:2]([NH:1][C:35]([NH:34][C:29]4[CH:30]=[C:31]([F:33])[CH:32]=[C:27]([F:26])[CH:28]=4)=[O:36])=[CH:7][CH:6]=3)=[CH:9][CH:10]=2)[C:14]1=[O:17])[CH:23]([CH3:25])[CH3:24]

참가 물질

3

반응물 2

HCID 27792821,3-Difluoro-5-isocyanatobenzeneHCID 131731441(S)-Methyl 2-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

생성물 1

HCID 67305419HCID 67305419, 화합물

실험 절차

The compound of example 29 was prepared analogous to compound of example 7 by reaction of compound of example 6 with 3,5-difluorophenyl isocyanate. The compound of example 29 was used directly without isolation for the preparation of compound of example 30.

출처 및 근거

ORD 기록
ord-847d86da92de4549beb7c0c35ce255b2
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08748426B2

연결된 노트

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