2-(Trifluoromethyl)phenyl isothiocyanate → (S)-Methyl 3-methyl-2-(1-oxo-5-(4-(3-(2-(trifluoromethyl)phenyl)thioureido)phenyl)isoindolin-2-yl)butanoate

HRID 403895

반응식

HRID 403895 반응식
F[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9](=[S:35])[NH:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]2[CH:18]=[C:19]3[C:23](=[CH:24][CH:25]=2)[C:22](=[O:26])[N:21]([C@@H:27]([CH:32]([CH3:34])[CH3:33])[C:28]([O:30][CH3:31])=[O:29])[CH2:20]3)=[CH:13][CH:12]=1.NC1C=CC(C2C=C3C(=CC=2)C(=O)N([C@@H](C(C)C)C(OC)=O)C3)=CC=1.[F:61][C:62]([F:73])([F:72])C1C=CC=CC=1N=C=S>>[CH3:33][CH:32]([CH3:34])[C@H:27]([N:21]1[CH2:20][C:19]2[C:23](=[CH:24][CH:25]=[C:17]([C:14]3[CH:13]=[CH:12][C:11]([NH:10][C:9]([NH:8][C:3]4[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=4[C:62]([F:73])([F:72])[F:61])=[S:35])=[CH:16][CH:15]=3)[CH:18]=2)[C:22]1=[O:26])[C:28]([O:30][CH3:31])=[O:29]

참가 물질

4

반응물 3

HCID 7371622-(Trifluoromethyl)phenyl isothiocyanateHCID 131731499(S)-Methyl 2-(5-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoateHCID 131731509(S)-Methyl 2-(5-(4-(3-(2-fluorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

생성물 1

HCID 131731515(S)-Methyl 3-methyl-2-(1-oxo-5-(4-(3-(2-(trifluoromethyl)phenyl)thioureido)phenyl)isoindolin-2-yl)butanoate

실험 절차

The compound of example 270 was prepared analogous to compound of example 256 by reaction of compound of example 223 with 2-trifluoromethyl phenyl isothiocyanate. The compound of example 270 was used directly without isolation, for the preparation of compound of example 271.

출처 및 근거

ORD 기록
ord-d1ae859955524f888709a20a69881c22
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08748426B2

연결된 노트

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