Tetrahydrofuran → N-(4-(2-Hydroxyethylidene)cyclohexyl)acetamide

HRID 404257

반응식

HRID 404257 반응식
[H-].[Na+].O=[C:4]1[CH2:9][CH2:8][CH:7]([NH:10][C:11](=[O:13])[CH3:12])[CH2:6][CH2:5]1.C1C[O:17][CH2:16][CH2:15]1>>[OH:17][CH2:16][CH:15]=[C:4]1[CH2:9][CH2:8][CH:7]([NH:10][C:11](=[O:13])[CH3:12])[CH2:6][CH2:5]1

참가 물질

4

반응물 3

HCID 8028Tetrahydrofuran2회HCID 24758Sodium hydrideHCID 538565N-(4-Oxocyclohexyl)acetamide

생성물 1

HCID 58294115N-(4-(2-Hydroxyethylidene)cyclohexyl)acetamide

실험 절차

To a stirred suspension of sodium hydride (1.2 mmol) in THF was added triethyl phosphonoacetate (1.2 mmol) drop wise. The mixture was allowed to stir until it became colorless and a solution of N-(4-oxocyclohexyl)acetamide (1.0 mmol) in THF (1 mL) was added. The solution was allowed to stir at rt until the reaction was complete (by TLC). The solvent was removed under reduced pressure and the crude residue was filtered through a small plug of silica gel to afford the desired product, which was used directly in the next synthetic step.

후처리

  1. stirringto stir at rt until the reaction
  2. customThe solvent was removed under reduced pressure
  3. filtrationthe crude residue was filtered through a small plug of silica gel

출처 및 근거

ORD 기록
ord-891f331053f1428a847cc69c037e3ac3
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08748469B2

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