Water → 1-(3-Chloropyridin-2-yl)piperidin-4-ol
반응식
Cl[C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][N:3]=1.O[CH:10]1[CH2:15][NH:14][CH2:13][CH2:12][CH2:11]1.[OH2:16]>CS(C)=O>[Cl:8][C:7]1[C:2]([N:14]2[CH2:13][CH2:12][CH:11]([OH:16])[CH2:10][CH2:15]2)=[N:3][CH:4]=[CH:5][CH:6]=1참가 물질
5
실험 절차
2,3-dichloropyridine (10 g, 68 mmol) and 5-hydroxyl piperidine (compound 19) (26 g, 272 mmol) in DMSO was heated at 120° C. and stirred overnight. After the reaction was completed, three times of water was added into the reaction solution. The reaction mixture was extracted by ethyl acetate. The organic layer was evaporated to give a crude product, which was purified using column chromatography to give the product. (17 g, 93%)
후처리
- extractionThe reaction mixture was extracted by ethyl acetate
- customThe organic layer was evaporated
출처 및 근거
- ORD 기록
- ord-f815850a6cf4438fa49e999c908cfc72
- 출처 데이터셋
- uspto-grants-2014_06
- 특허 번호
- US08748610B2
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