Benzoyl chloride → 3-(Chloromethyl)-5-phenyl-1,2,4-oxadiazole

HRID 404619

반응식

HRID 404619 반응식
[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:10][CH2:11][C:12](=[N:14]O)[NH2:13]>C(Cl)Cl.O>[Cl:10][CH2:11][C:12]1[N:14]=[C:1]([C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[O:8][N:13]=1

참가 물질

5

반응물 2

HCID 7412Benzoyl chlorideHCID 41122522-chloro-N'-hydroxyethanimidamide

생성물 1

HCID 3021543-(Chloromethyl)-5-phenyl-1,2,4-oxadiazole수율 44.8%

시약·촉매·용매 2

HCID 962Water용매HCID 6344Dichloromethane용매2회

실험 절차

Benzoyl chloride (1.60 ml, 13.8 mmol) was added to a suspension of 2-chloro-N′-hydroxyacetimidamide (1.0 g, 9.21 mmol) in DCM (25 ml), with stirring at room temperature. After 30 minutes, TEA (1.41 ml, 10.1 mmol) was added to the white suspension and the mixture was stirred for 30 additional minutes (UPLC-MS: complete conversion). The solution was diluted with DCM (20 ml) and water (30 ml) was added. The aqueous phase was extracted three times with DCM (15 ml×3) and then the combined organic phases were dried (Na2SO4) and evaporated. The crude was suspended in toluene (25 ml) and the mixture was heated to reflux for 6 h (UPLC-MS: complete conversion). The solvent was evaporated and the crude was purified by flash chromatography (petroleum ether/EtOAc=95/5) to obtain 3-(chloromethyl)-5-phenyl-1,2,4-oxadiazole (803 mg, 44.8% yield) as an off-white solid.

후처리

  1. stirringthe mixture was stirred for 30 additional minutes (UPLC-MS: complete conversion)
  2. additionwas added
  3. extractionThe aqueous phase was extracted three times with DCM (15 ml×3)
  4. dry with materialthe combined organic phases were dried (Na2SO4)
  5. customevaporated
  6. temperaturethe mixture was heated
  7. temperatureto reflux for 6 h (UPLC-MS: complete conversion)
  8. customThe solvent was evaporated
  9. customthe crude was purified by flash chromatography (petroleum ether/EtOAc=95/5)

출처 및 근거

ORD 기록
ord-031cd1f1b49c48b4b287179e59899b42
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08748613B2

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