Thiomorpholine → HCID 86688897, 화합물
반응식
Br[CH:2]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:3]([O:5][CH2:6][CH3:7])=[O:4].CCN(C(C)C)C(C)C.[NH:23]1[CH2:28][CH2:27][S:26][CH2:25][CH2:24]1>C(#N)C>[C:8]1([CH:2]([N:23]2[CH2:28][CH2:27][S:26][CH2:25][CH2:24]2)[C:3]([O:5][CH2:6][CH3:7])=[O:4])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1참가 물질
5
실험 절차
Ethyl 2-bromo-2-phenylacetate (0.22 ml, 1.23 mmol) was dissolved in acetonitrile (4.0 ml). DIPEA (0.26 ml, 1.481 mmol) and thiomorpholine (0.15 ml, 1.41 mmol) were sequentially added and the solution was stirred at room temperature for 1.5 hours. Acetonitrile was evaporated and the residue was purified by flash chromatography (petroleum ether/EtOAc=95/5) to obtain ethyl 2-phenyl-2-thiomorpholinoacetate (362 mg, quantitative yield) as a colorless oil.
후처리
- customAcetonitrile was evaporated
- customthe residue was purified by flash chromatography (petroleum ether/EtOAc=95/5)
출처 및 근거
- ORD 기록
- ord-ab62a2473b1041ffae859d6daacb56ae
- 출처 데이터셋
- uspto-grants-2014_06
- 특허 번호
- US08748613B2
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