2-(4'-Chloro-4-ethylbiphen-3-yl)-3-methoxycyclopent-2-enone → 2-(4'-Chloro-4-ethylbiphen-3-yl)-1,3-cyclopentanedione

HRID 40469노트

반응식

HRID 40469 반응식
[Cl:1][C:2]1[CH:23]=[CH:22][C:5]([C:6]2[CH:7]=[CH:8][C:9]([CH2:20][CH3:21])=[C:10]([C:12]3[C:13](=[O:19])[CH2:14][CH2:15][C:16]=3[O:17]C)[CH:11]=2)=[CH:4][CH:3]=1>CC(C)=O.Cl.O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]2[CH:7]=[CH:8][C:9]([CH2:20][CH3:21])=[C:10]([CH:12]3[C:13](=[O:19])[CH2:14][CH2:15][C:16]3=[O:17])[CH:11]=2)=[CH:22][CH:23]=1

참가 물질

5

반응물 1

HCID 585028162-(4'-Chloro-4-ethylbiphen-3-yl)-3-methoxycyclopent-2-enone

생성물 1

HCID 468300792-(4'-Chloro-4-ethylbiphen-3-yl)-1,3-cyclopentanedione

시약·촉매·용매 3

HCID 180Acetone용매HCID 313Hydrochloric Acid용매2회HCID 962Water용매

실험 절차

A solution of 2-(4′-chloro-4-ethylbiphen-3-yl)-3-methoxycyclopent-2-enone (200 mg, 0.61 mmol) in acetone (4 ml) and 2M aqueous hydrochloric acid (4 ml) is heated at 120° C. for 20 minutes under microwave irradiation. The reaction mixture is diluted with water (20 ml) and 2M aqueous hydrochloric acid (10 ml), and the crude product is extracted with ethyl acetate (3×15 ml). The organic extracts are combined, washed with brine (10 ml), dried over anhydrous magnesium sulfate, filtered and the filtrate is evaporated to dryness under reduced pressure to give 2-(4′-chloro-4-ethylbiphen-3-yl)-1,3-cyclopentanedione.

후처리

  1. extractionthe crude product is extracted with ethyl acetate (3×15 ml)
  2. washwashed with brine (10 ml)
  3. dry with materialdried over anhydrous magnesium sulfate
  4. filtrationfiltered
  5. customthe filtrate is evaporated to dryness under reduced pressure

출처 및 근거

ORD 기록
ord-6f7641894d3b4895a473f13086f5e497
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08530388B2

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