Morpholine → Methyl 5-bromo-2-morpholinobenzoate

온도

100 °C

To a solution of methyl 5-bromo-2-iodobenzoate (2.1 g, 6.16 mmol) in DME (15 mL) were morpholine (0.593 mL, 6.78 mmol), rac-2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl (0.384 g, 0.62 mmol), Palladium acetate (0.138 g, 0.62 mmol) and CESIUM CARBONATE (2.81 g, 8.62 mmol) added. The mixture was heated in the microwave oven for 1h. The solvent was evaporated and the crude product was added to a silica gel column, 0-25% EtOAc in heptane yielding [Products]

ORD 기록

ord-b45fc3e4fad4439cafccda47ed5c0991

출처 데이터셋

750 AstraZeneca ELN dataset

원본 링크

출처 보기