Acetic Anhydride → 4-Oxazolecarboxylic acid, 2-(acetylamino)-, ethyl ester

반응식

[CH2:1]([O:3][C:4]([C:6]1[N:7]=[C:8]([NH2:11])[O:9][CH:10]=1)=[O:5])[CH3:2].[C:12](OC(=O)C)(=[O:14])[CH3:13]>>[CH2:1]([O:3][C:4]([C:6]1[N:7]=[C:8]([NH:11][C:12](=[O:14])[CH3:13])[O:9][CH:10]=1)=[O:5])[CH3:2]

참가 물질

반응물 2

HCID 7918Acetic Anhydride

HCID 319549Ethyl 2-amino-1,3-oxazole-4-carboxylate

생성물 1

HCID 2153734-Oxazolecarboxylic acid, 2-(acetylamino)-, ethyl ester

실험 절차

1.0 g (6.40 mmol) 2-Amino-oxazole-4-carboxylic acid ethyl ester and 9.1 mL (96.3 mmol) acetic acid anhydride are stirred for 2 d at rt. The mixture is concentrated in vacuo to yield the desired product which is used without further purification.

후처리

concentrationThe mixture is concentrated in vacuo

출처 및 근거

ORD 기록: ord-57cff594de224c42a16d335ca7ca622e
출처 데이터셋: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08530461B2

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