Potassium Carbonate → 4-[(3-Methyl-1,2,4-oxadiazol-5-yl)methoxy]aniline

HRID 405339

반응식

[N+:1]([C:4]1[CH:17]=[CH:16][C:7]([O:8][CH2:9][C:10]2[O:14][N:13]=[C:12]([CH3:15])[N:11]=2)=[CH:6][CH:5]=1)([O-])=O.S(S([O-])=O)([O-])=O.[Na+].[Na+].C([O-])([O-])=O.[K+].[K+]>>[NH2:1][C:4]1[CH:17]=[CH:16][C:7]([O:8][CH2:9][C:10]2[O:14][N:13]=[C:12]([CH3:15])[N:11]=2)=[CH:6][CH:5]=1

참가 물질

반응물 3

HCID 11430Potassium Carbonate

HCID 24489Sodium Dithionite

HCID 220604453-Methyl-5-(4-nitrophenoxymethyl)-1,2,4-oxadiazole

생성물 1

HCID 220608734-[(3-Methyl-1,2,4-oxadiazol-5-yl)methoxy]aniline

실험 절차

In like manner to the preparation of 5-[(4-aminophenoxy)methyl]-3-phenyl-1,2,4-oxadiazole, 5-(4-nitrophenoxymethyl)-3-methyl-1,2,4-oxadiazole was reacted with aqueous solution of sodium hydrosulfite and K2CO3 to prepare 5-[(4-aminophenox)ymethyl]-3-methyl-1,2,4-oxadiazole. 1H NMR (CDCl3): δ 6.82 (d, 2H, J=8.8 Hz), 6.63 (d, 2H, J=8.8 Hz), 5.15 (s, 2H), 3.38 (br s, 2H), 2.41 (s, 3H).

출처 및 근거

ORD 기록: ord-b25c922b4e5b4df187fcd76c6090adb7
출처 데이터셋: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08748597B2

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