4-Isopropoxyaniline → 5-Fluoropyrimidine-2,4-diamine

HRID 405394

반응식

OC1C=C([NH:8][C:9]2[N:14]=[C:13]([NH:15]C3C=CC=C(O)C=3)[C:12]([F:23])=[CH:11][N:10]=2)C=CC=1.ClC1N=C(Cl)C(F)=CN=1.C(OC1C=CC(N)=CC=1)(C)C>>[F:23][C:12]1[C:13]([NH2:15])=[N:14][C:9]([NH2:8])=[N:10][CH:11]=1

참가 물질

반응물 3

HCID 821124-Isopropoxyaniline

HCID 2507052,4-Dichloro-5-fluoropyrimidine

HCID 9904854R-112

생성물 1

HCID 2556085-Fluoropyrimidine-2,4-diamine

실험 절차

In a manner similar to the preparation of N2,N4-bis(3-hydroxyphenyl)-5-fluoro-2,4-pyrimidinediamine, 2,4-dichloro-5-fluoropyrimidine and 4-isopropoxyaniline were reacted to yield N2,N4-bis(4-isopropoxy)phenyl)-5-fluoro-2,4-pyrimidinediamine. 1H NMR (CDCl3): δ 7.89 (bs, 1H), 7.47 (d, 2H, J=8.7 Hz), 7.38 (d, 2H, J=9.0 Hz), 6.87 (d, 2H, J=9.0 Hz), 6.83 (d, 2H, J=8.7 Hz); LCMS: ret. time: 27.51 min.; purity: 98%; MS (m/e): 397 (MH+).

후처리

customwere reacted

출처 및 근거

ORD 기록: ord-785436e8cb7047c2bb1b202c52e0b1a8
출처 데이터셋: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08748597B2

연결된 노트

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