Hydrochloric Acid → 1,1-Difluoro-6-azaspiro(2.5)octane hydrochloride

HRID 40547노트

반응식

HRID 40547 반응식
[F:1][C:2]1([F:13])[C:4]2([CH2:9][CH2:8][N:7](C(O)=O)[CH2:6][CH2:5]2)[CH2:3]1.[ClH:14]>ClCCl.O1CCOCC1>[ClH:14].[F:1][C:2]1([F:13])[C:4]2([CH2:9][CH2:8][NH:7][CH2:6][CH2:5]2)[CH2:3]1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 676079831,1-Difluoro-6-aza-spiro[2.5]octane-6-carboxylic acid

생성물 1

HCID 676082911,1-Difluoro-6-azaspiro(2.5)octane hydrochloride

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 312751,4-Dioxane용매

실험 절차

1.2 g of tert-butyl ester of 1,1-difluoro-6-aza-spiro[2.5]octane-6-carboxylic acid is put in 24 mL of dichloromethane. 24 mL of 4M hydrochloric acid in dioxane is added at room temperature. The solution is stirred for 4 h and is evaporated to dryness. 1 g of 1,1-difluoro-6-aza-spiro[2.5]octane hydrochloride is obtained.

후처리

  1. customis evaporated to dryness

출처 및 근거

ORD 기록
ord-afa3c5c465d949e0816334119236475a
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08530473B2

반응 노트

불러오는 중…