참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Acetic Anhydride | HCID 7918 | — |
| 반응물 | (alphaS)-4-Bromo-alpha-methylbenzenemethanamine | HCID 852999 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | N-((1S)-1-(4-Bromophenyl)ethyl)acetamide | HCID 793484 | — |
반응 단계
To 200 g (1.00 mol) (S)-1-(4-bromophenyl)ethylamine in 800 mL DCM are slowly added 94.5 mL (1.00 mol) acetic anhydride while cooling the mixture to 20-30° C. Then the cooling is removed and the reaction mixture is stirred at r.t. over night. Afterwards the mixture is consecutively washed with water, sat. aq. NaHCO3 solution, water, diluted aq. citric acid solution and again water. The org. layer is dried with MgSO4 and the solvent is removed in vacuo. The crude product is used without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08530460B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_09 |
|---|
| ORD ID | ord-79330a88ee4444a18d3c367b1401b50e |
|---|
| 출처 메모 | uspto-grants-2013_09 |
|---|
