反应详情

温度

25 °C

To 200 g (1.00 mol) (S)-1-(4-bromophenyl)ethylamine in 800 mL DCM are slowly added 94.5 mL (1.00 mol) acetic anhydride while cooling the mixture to 20-30° C. Then the cooling is removed and the reaction mixture is stirred at r.t. over night. Afterwards the mixture is consecutively washed with water, sat. aq. NaHCO3 solution, water, diluted aq. citric acid solution and again water. The org. layer is dried with MgSO4 and the solvent is removed in vacuo. The crude product is used without further purification.

1. customThen the cooling is removed
2. washAfterwards the mixture is consecutively washed with water, sat. aq. NaHCO3 solution, water, diluted aq. citric acid solution and again water
3. dry with materiallayer is dried with MgSO4
4. customthe solvent is removed in vacuo
5. customThe crude product is used without further purification