Acetonitrile → 5-Bromo-N-sec-butylpyrimidin-2-amine
반응식
[Br:1][C:2]1[CH:3]=[N:4][C:5](Cl)=[N:6][CH:7]=1.[CH:9]([NH2:13])([CH2:11][CH3:12])[CH3:10].C(#N)C>CCOC(C)=O>[Br:1][C:2]1[CH:3]=[N:4][C:5]([NH:13][CH:9]([CH2:11][CH3:12])[CH3:10])=[N:6][CH:7]=1참가 물질
5
반응 조건
- 온도
- 120 °C
실험 절차
In a sealed tube 2.00 g (10.3 mmol) 5-bromo-2-chloropyrimidine and 3.13 mL (31.0 mmol) sec-butylamin are added to 12 mL ACN. The reaction mixture is stirred at 120° C. for 2 h, then diluted with EtOAc and washed with water (2×). The org. phase is dried with MgSO4 and the solvent is removed in vacuo. C8H12BrN3 (M=230.1 g/mol)
후처리
- washwashed with water (2×)
- dry with materialphase is dried with MgSO4
- customthe solvent is removed in vacuo
출처 및 근거
- ORD 기록
- ord-1d99d59c38ef44dfa691cbcecf9f42e2
- 출처 데이터셋
- uspto-grants-2013_09
- 특허 번호
- US08530460B2
반응 노트
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