Benzoic Acid → 5-Chloro-2-phenyloxazolo[5,4-d]pyrimidine

HRID 40565노트

반응식

HRID 40565 반응식
[C:1]([OH:9])(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:10][C:11]1[N:16]=[CH:15][C:14]([NH2:17])=[C:13](Cl)[N:12]=1>O=P(Cl)(Cl)Cl>[Cl:10][C:11]1[N:12]=[CH:13][C:14]2[N:17]=[C:1]([C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[O:9][C:15]=2[N:16]=1

참가 물질

4

반응물 2

HCID 243Benzoic AcidHCID 2577975-Amino-2,4-dichloropyrimidine

생성물 1

HCID 149130905-Chloro-2-phenyloxazolo[5,4-d]pyrimidine

시약·촉매·용매 1

HCID 24813Phosphorus oxychloride용매

실험 절차

7.82 g (64.0 mmol) benzoic acid and 20 mL POCl3 are stirred together at 100° C. for 30 min. Within 45 min 7.00 g (42.7 mmol) 2,6-dichloro-5-aminopyrimidine are added by several portions. The reaction mixture is stirred for additional 2 h at the same temperatur. After that the mixture is carefully added to an ice cold aq. NaOH solution. The resulting precipitate is filtered, washed with water and dried.

후처리

  1. filtrationThe resulting precipitate is filtered
  2. washwashed with water
  3. customdried

출처 및 근거

ORD 기록
ord-0a7236edd7b34ad4bd3310e7c1c86518
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08530460B2

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