Ethyl Bromide → 2-Bromo-5-ethoxypyridine
반응식
Br[CH2:2][CH3:3].C([O-])([O-])=O.[K+].[K+].[Br:10][C:11]1[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][N:12]=1>C(#N)C>[Br:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][CH2:2][CH3:3])=[CH:13][N:12]=1참가 물질
5
실험 절차
2.51 g (22.99 mmol) 1-bromoethane and 1.99 g (14.37 mmol) K2CO3 are added to a mixture of 1.0 g (5.75 mmol) 2-bromo-5-hydroxypyridine in 100 mL ACN. The mixture is stirred at reflux over night. Then the reaction mixture is poured onto water and extracted with TBME. The organic layer is dried with Na2SO4 and the solvent is removed under vacuo. The residue is purified by column chromatography (silica gel, PE/EtOAC 1/1).
후처리
- temperatureat reflux over night
- additionThen the reaction mixture is poured onto water
- extractionextracted with TBME
- dry with materialThe organic layer is dried with Na2SO4
- customthe solvent is removed under vacuo
- customThe residue is purified by column chromatography (silica gel, PE/EtOAC 1/1)
출처 및 근거
- ORD 기록
- ord-52b68b2543574d2f8bafa4e5182d8539
- 출처 데이터셋
- uspto-grants-2013_09
- 특허 번호
- US08530460B2
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