Phosphorus oxychloride → 5-(Tert-butyl)-2-chloropyrimidine
반응식
[C:1]([C:5]1[CH:6]=[N:7][C:8](=O)[NH:9][CH:10]=1)([CH3:4])([CH3:3])[CH3:2].O=P(Cl)(Cl)[Cl:14]>>[C:1]([C:5]1[CH:6]=[N:7][C:8]([Cl:14])=[N:9][CH:10]=1)([CH3:4])([CH3:3])[CH3:2]참가 물질
3
실험 절차
200 mL POCl3 and 14 g (0.09 mol) 5-tert-butylpyrimidin-2(1H)-one are heated in a sealed glass ampoule for 3 h at 160° C. The mixture is cooled and the excess
후처리
- temperatureThe mixture is cooled
출처 및 근거
- ORD 기록
- ord-e6544b0204d542119421404452d51507
- 출처 데이터셋
- uspto-grants-2013_09
- 특허 번호
- US08530460B2
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