2-Amino-5-chlorophenol → HCID 58117890, 화합물

반응식

[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[OH:9].[N:10]1(C(OC(C)(C)C)=O)[CH2:15][CH2:14][CH:13]([C:16]([O-])=O)[CH2:12][CH2:11]1>>[Cl:8][C:5]1[CH:6]=[CH:7][C:2]2[N:1]=[C:16]([CH:13]3[CH2:14][CH2:15][NH:10][CH2:11][CH2:12]3)[O:9][C:3]=2[CH:4]=1

참가 물질

반응물 2

HCID 915912-Amino-5-chlorophenol

HCID 6921829HCID 6921829, 화합물

생성물 1

HCID 58117890HCID 58117890, 화합물수율 103.1%

실험 절차

500 mg 2-amino-5-chlorophenol and 800 mg mono-tert-butyl piperidine-1,4-dicarboxylate are heated to 200° C. in 4 ml polyphosphoric acid for 4 h. After cooling the reaction mixture is combined with ice water and stirred for 30 min. The precipitate is suction filtered, washed with water and dried. 850 mg product are obtained as the phosphate.

후처리

temperatureAfter cooling the reaction mixture
filtrationfiltered
washwashed with water
customdried

출처 및 근거

ORD 기록: ord-bfc808555a5742d8a71cbeab465bfb8f
출처 데이터셋: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08754073B2

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