Diisopropylethylamine → HCID 46913023, 화합물

HRID 405942

반응식

HRID 405942 반응식
[O:1]=[S:2]1[C:10]2[C:9]([NH:11][CH:12]3[CH2:17][CH2:16][O:15][CH2:14][CH2:13]3)=[N:8][C:7]([N:18]3[CH2:23][CH2:22][CH:21]([O:24][C:25]4[CH:33]=[CH:32][C:28]([C:29](O)=[O:30])=[CH:27][CH:26]=4)[CH2:20][CH2:19]3)=[N:6][C:5]=2[CH2:4][CH2:3]1.C([N:37]([CH:40]([CH3:42])[CH3:41])[CH2:38]C)(C)C.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.Cl.C1(CN)CC1>CN(C)C=O>[CH:40]1([N:37]([CH3:38])[C:29](=[O:30])[C:28]2[CH:27]=[CH:26][C:25]([O:24][CH:21]3[CH2:20][CH2:19][N:18]([C:7]4[N:8]=[C:9]([NH:11][CH:12]5[CH2:17][CH2:16][O:15][CH2:14][CH2:13]5)[C:10]5[S:2](=[O:1])[CH2:3][CH2:4][C:5]=5[N:6]=4)[CH2:23][CH2:22]3)=[CH:33][CH:32]=2)[CH2:41][CH2:42]1

참가 물질

6

반응물 4

HCID 81531DiisopropylethylamineHCID 81671(Cyclopropylmethyl)ammonium chlorideHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 46912845HCID 46912845, 화합물

생성물 1

HCID 46913023HCID 46913023, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

55 mg of Example 184 (see 40.) are placed in 2 ml dimethylformamide, then 81 l diisopropylethylamine and 53.1 mg O-(7-azabenzotriazol-1-yl-)-N,N,N′,N′-tetramethyluronium hexafluorophosphate (HATU) are added. After 15 min 13.8 mg cyclopropylmethylamine hydrochloride are added. The reaction mixture is stirred at ambient temperature until there is no further reaction and the product is purified directly by preparative HPLC (method B). 30 mg of Example 242 are obtained as a solid.

후처리

  1. customno further reaction
  2. customthe product is purified directly by preparative HPLC (method B)

출처 및 근거

ORD 기록
ord-f5998a79fbcc4c73bfae8095fdc14141
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08754073B2

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