Thionyl Chloride → 4,6-Dichloropyrimidine-5-carbonitrile
반응식
[Cl:1][C:2]1[C:7]([CH:8]=[N:9]O)=[C:6]([Cl:11])[N:5]=[CH:4][N:3]=1.O=S(Cl)Cl>C(Cl)(Cl)Cl>[Cl:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([Cl:11])[N:5]=[CH:4][N:3]=1참가 물질
4
실험 절차
4,6-Dichloropyrimidine-5-carbaldehyde oxime (8g) was dissolved in CHCl3 (40 mL) and treated with SOCl2 (6 mL) for 2 h at rt. The solvent was removed and redissolved in DCM (5 mL). The solid was filtered and washed with DCM (5 mL). The filtrate was concd and purified by column chromatography on silica gel (dry loading, DCM/hexane, 3/1) to give 4,6-dichloropyrimidine-5-carbonitrile as a white solid.
후처리
- customThe solvent was removed
- dissolutionredissolved in DCM (5 mL)
- filtrationThe solid was filtered
- washwashed with DCM (5 mL)
- custompurified by column chromatography on silica gel (dry loading, DCM/hexane, 3/1)
출처 및 근거
- ORD 기록
- ord-9fa181c8e34b4f3c9ff0d21fac8ae88f
- 출처 데이터셋
- uspto-grants-2014_06
- 특허 번호
- US08754089B2
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