1,4-Dioxane → HCID 178441228, 화합물

HRID 406280노트

반응식

HRID 406280 반응식
CC([N:5]([C@H:9]1[CH2:12][C@H:11]([O:13][C:14]2[CH:19]=[C:18]([F:20])[C:17]([C:21]([CH3:24])([CH3:23])[CH3:22])=[C:16]([F:25])[CH:15]=2)[CH2:10]1)C(=O)[O-])(C)C.O1CCOCC1>Cl>[CH3:24][C:21]([C:17]1[C:16]([F:25])=[CH:15][C:14]([O:13][C@H:11]2[CH2:10][C@H:9]([NH2:5])[CH2:12]2)=[CH:19][C:18]=1[F:20])([CH3:22])[CH3:23]

참가 물질

4

반응물 2

HCID 312751,4-DioxaneHCID 178441233HCID 178441233, 화합물

생성물 1

HCID 178441228HCID 178441228, 화합물수율 77.1%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

1,1-dimethylethyl(trans-3-{[4-(1,1-dimethylethyl)-3,5-difluorophenyl]oxy}cyclobutyl)carbamate (257 mg, 0.723 mmol) was stirred in 4M HCl in dioxane (5 mL, 20 mmol) overnight and then concentrated in vacuo and loaded onto an SCX cartridge (10 g) and eluted with MeOH (3 column volumes) and then flushed with ammonia in MeOH. Concentration of the product containing fractions in vacuo gave the title compound (142.3 mg).

후처리

  1. concentrationconcentrated in vacuo
  2. washeluted with MeOH (3 column volumes)
  3. customflushed with ammonia in MeOH
  4. additionConcentration of the product containing fractions in vacuo

출처 및 근거

ORD 기록
ord-77cc67c5070c4109934745d28da33a67
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08754101B2

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