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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Diisopropylethylamine → (S)-1-(1-Methyl-1H-indol-4-yloxy)-3-(9-naphthalen-2-yl-7,9-diaza-bicyclo[4.2.2]dec-3-en-7-yl)-propan-2-ol

HRID 40635
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인쇄 미리보기

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HRID 40635 반응식
[CH3:1][N:2]1[C:10]2[C:5](=[C:6]([O:11][CH2:12][C@@H:13]3[CH2:15][O:14]3)[CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3]1.[CH:16]1[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:19]=[CH:18][C:17]=1[N:26]1[CH2:33][C@H:32]2[NH:34][CH2:35][C@@H:27]1[CH2:28][CH:29]=[CH:30][CH2:31]2.CCN(C(C)C)C(C)C>C(O)C>[CH3:1][N:2]1[C:10]2[C:5](=[C:6]([O:11][CH2:12][C@@H:13]([OH:14])[CH2:15][N:34]3[CH2:35][CH:27]4[N:26]([C:17]5[CH:18]=[CH:19][C:20]6[C:25](=[CH:24][CH:23]=[CH:22][CH:21]=6)[CH:16]=5)[CH2:33][CH:32]3[CH2:31][CH:30]=[CH:29][CH2:28]4)[CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3]1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 81531DiisopropylethylamineHCID 59686815(2S)-Glycidyl 1-methylindol-4-yl etherHCID 59686818Z-(1S,6S)-7-naphthalen-2-yl-7,9-diaza-bicyclo[4.2.2]dec-3-ene

생성물 1

HCID 69233735(S)-1-(1-Methyl-1H-indol-4-yloxy)-3-(9-naphthalen-2-yl-7,9-diaza-bicyclo[4.2.2]dec-3-en-7-yl)-propan-2-ol

시약·촉매·용매 1

HCID 702Ethanol용매

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온도
120 °C

실험 절차

(S)-1-Methyl-4-oxiranylmethoxy-1H-indole (50 mg, 0.25 mmol) and Z-(1S,6S)-7-naphthalen-2-yl-7,9-diaza-bicyclo[4.2.2]dec-3-ene (50 mg, 0.189 mmol) were placed in a μW tube with ethanol (2 ml), DIPEA (100 μL, 0.576 mmol) and heated to 120° C. for 900 sec. The solvent was evaporated from the reaction mixture and the residue was purified via flash chromatography (gradient 30% to 100% ethyl acetate/heptane) to yield the title compound as a residue.

후처리

  1. customThe solvent was evaporated from the reaction mixture
  2. customthe residue was purified via flash chromatography (gradient 30% to 100% ethyl acetate/heptane)

출처 및 근거

ORD 기록
ord-ddd004fecaf94130b2abbe57112a1163
출처 데이터셋
uspto-grants-2013_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08530475B2

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