Hydrazine hydrate (1:1) → N-(4-(6-hydrazinylpyridazin-3-yl)phenyl)methanesulfonamide

반응식

Cl[C:2]1[N:7]=[N:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([NH:14][S:15]([CH3:18])(=[O:17])=[O:16])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.O.[NH2:20][NH2:21]>>[NH:20]([C:2]1[N:7]=[N:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([NH:14][S:15]([CH3:18])(=[O:17])=[O:16])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1)[NH2:21]

참가 물질

반응물 2

HCID 24654Hydrazine hydrate (1:1)

HCID 86650228N-(4-(6-chloropyridazin-3-yl)phenyl)methanesulfonamide

생성물 1

HCID 66849307N-(4-(6-hydrazinylpyridazin-3-yl)phenyl)methanesulfonamide

실험 절차

A suspension of N-(4-(6-chloropyridazin-3-yl)phenyl)methanesulfonamide (2.82 mmole) in hydrazine monohydrate (6 mL) was heated at 120 C for 1 hour and evaporated in vacuo. The residue was dissolved in dicholomethane, washed with water, dried over Na2SO4, and evaporated in vacuo to afford N-(4-(6-hydrazinylpyridazin-3-yl)phenyl)methanesulfonamide.

후처리

temperaturewas heated at 120 C for 1 hour
customevaporated in vacuo
dissolutionThe residue was dissolved in dicholomethane
washwashed with water
dry with materialdried over Na2SO4
customevaporated in vacuo

출처 및 근거

ORD 기록: ord-ce2e129202b841589782076f51956f05
출처 데이터셋: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08754103B2

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