Diisopropylethylamine → 1-(9-Naphthalen-2-yl-7,9-diaza-bicyclo[4.2.2]dec-3-en-7-yl)-3-(quinolin-5-yloxy)-propan-2-ol

HRID 40650노트

반응식

HRID 40650 반응식
[O:1]1[CH2:3][CH:2]1[CH2:4][O:5][C:6]1[CH:15]=[CH:14][CH:13]=[C:12]2[C:7]=1[CH:8]=[CH:9][CH:10]=[N:11]2.[CH:16]1[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:19]=[CH:18][C:17]=1[N:26]1[CH2:33][CH:32]2[NH:34][CH2:35][CH:27]1[CH2:28][CH:29]=[CH:30][CH2:31]2.CCN(C(C)C)C(C)C>C(O)C>[CH:16]1[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:19]=[CH:18][C:17]=1[N:26]1[CH2:33][CH:32]2[N:34]([CH2:3][CH:2]([OH:1])[CH2:4][O:5][C:6]3[CH:15]=[CH:14][CH:13]=[C:12]4[C:7]=3[CH:8]=[CH:9][CH:10]=[N:11]4)[CH2:35][CH:27]1[CH2:28][CH:29]=[CH:30][CH2:31]2

참가 물질

5

반응물 3

HCID 81531DiisopropylethylamineHCID 112178995-(Oxiran-2-ylmethoxy)quinolineHCID 692305417-Naphthalen-2-yl-7,9-diaza-bicyclo[4.2.2]dec-3-ene

생성물 1

HCID 692320141-(9-Naphthalen-2-yl-7,9-diaza-bicyclo[4.2.2]dec-3-en-7-yl)-3-(quinolin-5-yloxy)-propan-2-ol

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

5-Oxiranylmethoxy-quinoline (13 mg, 0.065 mmol), 7-naphthalen-2-yl-7,9-diaza-bicyclo[4.2.2]dec-3-ene (20 mg, 0.042 mmol), DIPEA (0.1 mL, 0.55 mmol) and ethanol (2 mL) were μW for 900 sec at 130° C. in a μW reaction tube. The solvent was evaporated in vacuo to yield a crude solid that was purified with flash chromatography gradient [30% EtOAc/heptane to 100% EtOAc] to yield the title compound as its free base, as a residue.

후처리

  1. customThe solvent was evaporated in vacuo
  2. customto yield a crude solid
  3. customthat was purified with flash chromatography gradient [30% EtOAc/heptane to 100% EtOAc]

출처 및 근거

ORD 기록
ord-4016b14be0524f859af083ea4e2b86d0
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08530475B2

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