Methylamine → Methyl 3-(methylamino)but-2-enoate

HRID 406576노트

반응식

HRID 406576 반응식
[C:1]([O:7][CH3:8])(=[O:6])[CH2:2][C:3]([CH3:5])=O.[CH3:9][NH2:10]>O>[CH3:9][NH:10][C:3]([CH3:5])=[CH:2][C:1]([O:7][CH3:8])=[O:6]

참가 물질

4

반응물 2

HCID 6329MethylamineHCID 7757Methyl acetoacetate

생성물 1

HCID 2734182Methyl 3-(methylamino)but-2-enoate수율 80.9%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a mixture of methyl acetoacetate (23.2 g, 0.2 mol) in water (15 mL) at 10° C. was added dropwise methylamine (40% aqueous solution, 18.6 g, 0.24 mol). The reaction mixture was allowed to warm to room temperature and stirred for 2 h. The resulting solid precipitate was collected by filtration and washed with ice water (2×), and then dried in a vacuum oven at 55° C. overnight to provide the title compound as a white solid (20.9 g).

후처리

  1. filtrationThe resulting solid precipitate was collected by filtration
  2. washwashed with ice water (2×)
  3. customdried in a vacuum oven at 55° C. overnight

출처 및 근거

ORD 기록
ord-3ba519176bf343d28ba6aba20ef70601
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08754115B2

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