Methylhydrazine → methyl 5-(2-chloro-4-fluorophenyl)-1,3-dimethyl-1H-pyrazole-4-carboxylate

HRID 406578노트

반응식

HRID 406578 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9](=O)[C:10](=[C:15]([NH:17]C)[CH3:16])[C:11]([O:13][CH3:14])=[O:12].[CH3:20][NH:21]N>C(OCC)C>[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:21]([CH3:20])[N:17]=[C:15]([CH3:16])[C:10]=1[C:11]([O:13][CH3:14])=[O:12]

참가 물질

4

반응물 2

HCID 6061MethylhydrazineHCID 178483602HCID 178483602, 화합물2회

생성물 1

HCID 66614282methyl 5-(2-chloro-4-fluorophenyl)-1,3-dimethyl-1H-pyrazole-4-carboxylate

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

A mixture of methyl 2-chloro-4-fluoro-α-[1-(methylamino)ethylidene]-β-oxobenzenepropanoate (i.e. the product of Step B) (15.91 g, 55.82 mmol) and methylhydrazine (3 mL, 56 mmol) in diethyl ether (150 mL) was stirred at room temperature for 48 h. The reaction mixture was concentrated under reduced pressure to provide the title compound as a colorless oil (15 g).

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-d3095b6652304e58bf35eec1cd198032
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08754115B2

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