Dimethylformamide → 5-Bromo-1-(cyclopropylmethyl)-1,2-dihydropyridin-2-one

HRID 406739

반응식

HRID 406739 반응식
[CH3:1][C:2]([O-])([CH3:4])[CH3:3].[K+].[Br:7][C:8]1[CH:9]=[CH:10][C:11](=[O:14])[NH:12][CH:13]=1.C1(CBr)CC1.CN(C)C=O>O1CCCC1.C(OCC)(=O)C>[Br:7][C:8]1[CH:9]=[CH:10][C:11](=[O:14])[N:12]([CH2:1][CH:2]2[CH2:4][CH2:3]2)[CH:13]=1

참가 물질

7

반응물 4

HCID 6228DimethylformamideHCID 81503BromomethylcyclopropaneHCID 5995285-Bromo-2-hydroxypyridineHCID 23665647Potassium tert-butoxide

생성물 1

HCID 596357015-Bromo-1-(cyclopropylmethyl)-1,2-dihydropyridin-2-one

시약·촉매·용매 2

HCID 8028Tetrahydrofuran용매HCID 8857Ethyl Acetate용매

반응 조건

온도
70 °C

실험 절차

KOtBu (0.68 g) was added to a solution of 5-bromo-1H-pyridin-2-one (1.00 g) in tetrahydrofuran (20 mL) at room temperature. After stirring for 30 min, cyclopropylmethyl bromide (0.77 mL) and dimethylformamide (3 mL) were added to the suspension and the resulting mixture was warmed to 70° C. After stirring the mixture at 70° C. for 2 h, the reaction was complete. The mixture was cooled to room temperature, diluted with ethyl acetate (50 mL), and washed with water (2×20 mL) and brine (20 mL). Then, the solution was dried (MgSO4) and the solvent was removed to give the title compound as a colorless oil. Yield: 1.18 g (90% of theory). Mass spectrum (ESI+): m/z=228/230 (Br) [M+H]+

후처리

  1. stirringAfter stirring the mixture at 70° C. for 2 h
  2. temperatureThe mixture was cooled to room temperature
  3. washwashed with water (2×20 mL) and brine (20 mL)
  4. dry with materialThen, the solution was dried (MgSO4)
  5. customthe solvent was removed

출처 및 근거

ORD 기록
ord-9bfaa689c8aa4cc797aef459d43e459a
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08754076B2

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