Triphosgene → (S)-1-Bromo-4-(1-isocyanato-ethyl)-2-methyl-benzene

HRID 406776

반응식

HRID 406776 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([NH2:10])[CH3:9])=[CH:4][C:3]=1[CH3:11].Cl[C:13](Cl)([O:15]C(=O)OC(Cl)(Cl)Cl)Cl.C1(C2(CC(O)(C)C)OC(=O)N([C@H](C3C=CC(C4C=CN(C)C(=O)C=4)=CC=3)C)CC2)CC1>CO>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([N:10]=[C:13]=[O:15])[CH3:9])=[CH:4][C:3]=1[CH3:11]

참가 물질

5

반응물 3

HCID 94429TriphosgeneHCID 58102381(S)-1-(4-Bromo-3-methylphenyl)ethan-1-amineHCID 596356736-cyclopropyl-6-(2-hydroxy-2-methylpropyl)-3-((S)-1-(4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl)ethyl)-1,3-oxazinan-2-one

생성물 1

HCID 86649416(S)-1-Bromo-4-(1-isocyanato-ethyl)-2-methyl-benzene

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

The title compound was prepared from (S)-1-(4-bromo-3-methyl-phenyl)-ethylamine and triphosgene following a procedure analogous to that described in Step 4 of Intermediate 1. Mass spectrum (ESI+): m/z=272/274 (Br) [M+H+MeOH]+.

출처 및 근거

ORD 기록
ord-7cb1a4eaa57a4ea2a339eee011e1b6cd
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08754076B2

연결된 노트

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