Hydrochloric Acid → Hydrochloric Acid

HRID 406992노트

반응식

HRID 406992 반응식
C(OC([N:6]1[CH:10]=[C:9]([C:11]2[CH:34]=[CH:33][C:14]3[N:15]([C:18]4[CH:19]=[C:20]([NH:24][C:25]([NH:27][CH2:28][C:29]([F:32])([F:31])[F:30])=[O:26])[CH:21]=[CH:22][CH:23]=4)[CH:16]=[N:17][C:13]=3[CH:12]=2)[CH:8]=[N:7]1)C)C.[ClH:35].O>O1CCCC1>[NH:6]1[CH:10]=[C:9]([C:11]2[CH:34]=[CH:33][C:14]3[N:15]([C:18]4[CH:19]=[C:20]([NH:24][C:25]([NH:27][CH2:28][C:29]([F:32])([F:31])[F:30])=[O:26])[CH:21]=[CH:22][CH:23]=4)[CH:16]=[N:17][C:13]=3[CH:12]=2)[CH:8]=[N:7]1.[ClH:35]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 67980487N-(3-{5-[1-(1-ethoxyethyl)-1H-pyrazol-4-yl]-1H-benzimidazol-1-yl]phenyl)-N'-(2,2,2-trifluoroethyl)urea

생성물 2

HCID 313Hydrochloric AcidHCID 67980057N-{3-[5-(1H-pyrazol-4-yl)-1H-benzimidazol-1-yl]phenyl}-N'-(2,2,2-trifluoroethyl)urea

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

The mixture of N-(3-{5-[1-(1-ethoxyethyl)-1H-pyrazol-4-yl]-1H-benzimidazol-1-yl}phenyl)-N′-(2,2,2-trifluoroethyl)urea (190 mg, 0.40 mmol) and 1.0 M hydrogen chloride in water (3 mL, 3 mmol) in tetrahydrofuran (5 mL) was stirred at r.t. 2 hours. The reaction mixture was concentrated under reduced pressure to dryness to afford the desired compound as HCl salt which was directly used in next step reaction without further purification. LCMS (M+H)+: m/z=401.2.

후처리

  1. custom2 hours
  2. concentrationThe reaction mixture was concentrated under reduced pressure to dryness

출처 및 근거

ORD 기록
ord-661cda71e74b4fae9c3a179727984545
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08754114B2

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