반응식
[C:1]([CH2:3][C:4]1([N:8]2[CH:12]=[C:11]([C:13]3[CH:18]=[N:17][N:16]4[C:19]([C:22]5[CH:23]=[C:24]([NH:28][C:29]([NH:31][CH2:32][C:33]([F:36])([F:35])[F:34])=[O:30])[CH:25]=[CH:26][CH:27]=5)=[CH:20][N:21]=[C:15]4[CH:14]=3)[CH:10]=[N:9]2)[CH2:7][NH:6][CH2:5]1)#[N:2].[C:37]([C:39]1([C:42](O)=[O:43])[CH2:41][CH2:40]1)#[N:38]>>[C:37]([C:39]1([C:42]([N:6]2[CH2:5][C:4]([N:8]3[CH:12]=[C:11]([C:13]4[CH:18]=[N:17][N:16]5[C:19]([C:22]6[CH:23]=[C:24]([NH:28][C:29]([NH:31][CH2:32][C:33]([F:35])([F:36])[F:34])=[O:30])[CH:25]=[CH:26][CH:27]=6)=[CH:20][N:21]=[C:15]5[CH:14]=4)[CH:10]=[N:9]3)([CH2:3][C:1]#[N:2])[CH2:7]2)=[O:43])[CH2:41][CH2:40]1)#[N:38]참가 물질
3
반응물 2
생성물 1
실험 절차
This compound was prepared by using procedures analogous to those described for the synthesis of Example 77 starting from N-[3-(7-{1-[3-(cyanomethyl)azetidin-3-yl]-1H-pyrazol-4-yl}imidazo[1,2-b]pyridazin-3-yl)phenyl]-N′-(2,2,2-trifluoroethyl)urea and 1-cyanocyclopropanecarboxylic acid. LCMS (M+H)+: m/z=589.2.
후처리
- customThis compound was prepared
출처 및 근거
- ORD 기록
- ord-add1c920ac3a48d8bae2fc7064d5c26a
- 출처 데이터셋
- uspto-grants-2014_06
- 특허 번호
- US08754114B2
연결된 노트
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