Hydrochloric Acid → Methyl 3-(6-aminopyridazin-4-yl)benzoate

HRID 407075노트

반응식

HRID 407075 반응식
Cl.C1(C(=[N:15][C:16]2[N:21]=[N:20][CH:19]=[C:18]([C:22]3[CH:23]=[C:24]([CH:29]=[CH:30][CH:31]=3)[C:25]([O:27][CH3:28])=[O:26])[CH:17]=2)C2C=CC=CC=2)C=CC=CC=1.C([O-])([O-])=O.[Na+].[Na+]>C1COCC1>[NH2:15][C:16]1[N:21]=[N:20][CH:19]=[C:18]([C:22]2[CH:23]=[C:24]([CH:29]=[CH:30][CH:31]=2)[C:25]([O:27][CH3:28])=[O:26])[CH:17]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 10340Sodium CarbonateHCID 86667185Methyl 3-{6-[(diphenylmethylene)amino]pyridazin-4-yl}benzoate

생성물 1

HCID 67980189Methyl 3-(6-aminopyridazin-4-yl)benzoate수율 218.1%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

1.0 M HCl (2.0 mL) was added to a solution of methyl 3-{6-[(diphenylmethylene)amino]pyridazin-4-yl}benzoate (0.16 g, 0.40 mmol) in THF (4.0 mL) and then the reaction was stirred at r.t. for 1.5 h. The mixture was carefully neutralized with Na2CO3 (2.0 eq) and then concentrated under reduced pressure to give the crude product (0.20 g) which was directly used in the next reaction without further purification. LCMS (M+H)+: m/z=230.1

후처리

  1. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-ca1d88af2bcf43728a4c01ba018c8fa3
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08754114B2

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