Triethyl phosphite → 5-Bromo-6-chlorobenzo[c][1,2,5]oxadiazole

HRID 407113노트

반응식

HRID 407113 반응식
P(OCC)(OCC)OCC.[Br:11][C:12]1[C:13]([Cl:22])=[CH:14][C:15]2[C:16]([CH:21]=1)=[N+:17]([O-])[O:18][N:19]=2.[O-]Cl.[Na+]>C(O)C>[Br:11][C:12]1[C:13]([Cl:22])=[CH:14][C:15]2=[N:19][O:18][N:17]=[C:16]2[CH:21]=1

참가 물질

5

반응물 3

HCID 31215Triethyl phosphiteHCID 23665760Sodium HypochloriteHCID 674650696-Bromo-5-chlorobenzo[c][1,2,5]oxadiazole 1-oxide

생성물 1

HCID 674684685-Bromo-6-chlorobenzo[c][1,2,5]oxadiazole

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
79 °C

실험 절차

P(OEt)3 (0.9 mL, 903 mg, 5.4 mmol) was added to a solution of bromide 93 (904 mg, 3.6 mmol) in ethanol at 79° C. The resulting mixture was stirred at 79° C. for 4 h. The mixture was then cooled in an ice bath and NaOCl (19 mL of a 10-15% sol, 1.2 g, 16 mmol) was added. The solution was cooled and concentrated under reduced pressure to provided crude 94.

후처리

  1. temperatureThe mixture was then cooled in an ice bath
  2. temperatureThe solution was cooled
  3. concentrationconcentrated under reduced pressure
  4. customto provided crude 94

출처 및 근거

ORD 기록
ord-451657bf30944838b09046134405184c
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08754219B2

반응 노트

불러오는 중…