Hydrazine hydrate (1:1) → HCID 178434638, 화합물

HRID 407297노트

반응식

HRID 407297 반응식
[Br:1][C:2]1[CH:17]=[CH:16][C:5]2[N:6]=[C:7]([C:9](=[C:12](OC)[CH3:13])[C:10]#[N:11])[S:8][C:4]=2[CH:3]=1.O.[NH2:19][NH2:20]>CO>[Br:1][C:2]1[CH:17]=[CH:16][C:5]2[N:6]=[C:7]([C:9]3[C:12]([CH3:13])=[N:20][NH:19][C:10]=3[NH2:11])[S:8][C:4]=2[CH:3]=1

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 667681932-(6-Bromobenzothiazol-2-yl)-3-methoxybut-2-enenitrile

생성물 1

HCID 178434638HCID 178434638, 화합물수율 5%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 2-(6-bromobenzothiazol-2-yl)-3-methoxybut-2-enenitrile (0.96 g, 3.1 mmol) and hydrazine hydrate (0.3 mL, 5.4 mmol) in methanol (30 mL) was heated to reflux overnight. The reaction was then cooled to room temperature. The resulting solid was isolated by filtration and was purified by flash chromatography to yield the title product. MS (m/z, ES+): 308.9 (Br79M+1, 100%), 310.9 (Br81 M+1, 100%). Yield=5%.

후처리

  1. temperatureto reflux overnight
  2. customThe resulting solid was isolated by filtration
  3. customwas purified by flash chromatography

출처 및 근거

ORD 기록
ord-4e2fc4d333084e0a8d5c1084ab90a73f
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08754233B2

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